5-Amino-1MQ Concentration Calculator

Classification: Synthetic small-molecule nicotinamide N-methyltransferase (NNMT) inhibitor; not a classical peptide.

Overview

5-Amino-1MQ is a compact synthetic molecule also called 5-amino-1-methylquinolinium. Its name can make it look like a peptide entry in a catalog, but its chemistry is different: it is a small-molecule quinolinium compound. The “MQ” shorthand refers to the methylquinolinium scaffold, not to an amino-acid chain.

The calculator is an arithmetic interface for a visitor who already has a label value and a liquid volume. It does not identify a product, assess identity, or decide whether a material is suitable for any purpose. Every displayed result is derived from the values entered into the form.

NNMT is an enzyme involved in methyl-group transfer and nicotinamide-related metabolism. Published work on 5-Amino-1MQ examines inhibition of that enzyme in experimental systems. A biological mechanism observed in a model is not evidence of a clinical outcome, and this page makes no claim about body weight, metabolic improvement, or treatment.

Research context

Primary research reported membrane-permeable NNMT inhibitors and evaluated 5-Amino-1MQ in cultured adipocyte-related systems and diet-related mouse experiments. Those designs can help investigate target biology, but they do not establish human efficacy or safety.

A later review places NNMT within broader obesity and type-two-diabetes biology and discusses inhibitor development as a research topic. Review context is useful for locating hypotheses, yet it should not be read as proof that any particular inhibitor has a validated clinical role.

Evidence and regulatory status

The evidence linked below supports the compound identity and preclinical research context. It does not support a claim that 5-Amino-1MQ is approved, established, or clinically validated.

ClinicalTrials.gov is provided as a searchable public registry rather than as proof that no undisclosed work exists. FDA approval, an investigational authorization, a publication, and a registry entry are different kinds of records and should not be conflated.

Unit notes

Mass entries may be expressed in mg or mcg. The universal relationship is 1 mg = 1,000 mcg; the calculator uses that relationship only to normalize the visitor’s entries.

Liquid volume is entered in mL. Concentration is normalized mass per mL, and the represented volume is normalized mass divided by that concentration.

U-100 means 100 units per mL and U-40 means 40 units per mL. These are display scales, not compound properties and not recommendations. Identical scale-unit counts can therefore represent different volumes on different scales.

A syringe position cannot be converted directly to mass without a concentration. The interface reports the arithmetic result and does not describe physical handling.

Limitations

• The calculator cannot verify whether a label really contains 5-Amino-1MQ, distinguish a salt from a free form, detect degradation, or evaluate contamination. It also cannot determine whether the liquid volume entered was measured accurately.
• The page intentionally avoids selecting an amount or use setting. Questions about a real material, an individual, or a regulated product require an appropriately qualified professional and the applicable official labeling.

Frequently asked questions

Sources and official references

• Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice — Scientific Reports via PubMed Central (2018)
• Roles of Nicotinamide N-Methyltransferase in Obesity and Type 2 Diabetes — Frontiers in Endocrinology via PubMed Central (2021)
• ClinicalTrials.gov search for 5-amino-1MQ — U.S. National Library of Medicine

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