SS-31 / Elamipretide Reconstitution Calculator

Classification: Mitochondria-targeting tetrapeptide; elamipretide (SS-31)

Overview

SS-31 is the research name for elamipretide, a mitochondria-targeting peptide. Scientific literature describes a short aromatic-cationic peptide that associates with mitochondrial membranes, including cardiolipin-containing membranes. The name SS-31 remains common in laboratory and clinical literature, while elamipretide is the nonproprietary name used in regulatory material. Forzinity is a product name, not a generic synonym for every container or research material carrying an SS-31 label.

The calculator is concerned only with dimensional arithmetic. A visitor enters the mass printed on a container, the liquid volume actually recorded for that container, an amount to calculate, and a syringe scale when applicable. PepLedger does not select an amount, infer a product label, identify a diluent, or decide whether a particular product is appropriate. A result is therefore a mathematical representation of the supplied entries, not a clinical instruction.

The FDA approval changes the regulatory context in an important, narrow way. The agency’s September 2025 announcement identifies Forzinity as an accelerated approval for Barth syndrome, a rare inherited mitochondrial disorder. The approved product and its labeling are authoritative for that product and indication. They do not make an unapproved SS-31 container interchangeable with Forzinity, and they do not support extrapolation to unrelated conditions.

ClinicalTrials.gov records show that elamipretide has also been studied in interventional research. A trial record is evidence that a study was registered; it is not evidence that an intervention is beneficial, suitable, or approved for a reader. Published reviews likewise organize a developing evidence base and may discuss proposed mechanisms without proving clinical outcomes. PepLedger keeps those categories separate.

Concentration depends on the visitor-entered mass and liquid volume. Altering the volume changes the arithmetic concentration even when the mass is unchanged. Syringe-scale units describe a volume marking and cannot identify a mass without the entered concentration and a consistent unit system.

Use the approved label and qualified professional sources for any product-specific question. This page does not provide preparation, administration, storage, route, schedule, or amount information. It also does not verify authenticity, sterility, identity, or concentration of a container. The safest interpretation of the output is simply: arithmetic performed on the visitor’s own entries.

Research context

Research has investigated membrane association, cardiolipin interactions, mitochondrial structure, and downstream cellular processes. Clinical studies have evaluated elamipretide in defined populations, but a registered study, a mechanistic paper, and an approved indication answer different questions. This record therefore describes the evidence categories rather than promising a biological result.

Evidence and regulatory status

The FDA announcement and Drug Trials Snapshot support the current Forzinity approval statement. The PubMed review and primary membrane study support the mitochondria-targeting and membrane-biology description. ClinicalTrials.gov supports the existence of registered elamipretide research. None of those sources supplies a personal calculator value.

Unit notes

Mass entries use mg or mcg. The universal relationship is 1 mg = 1,000 mcg.

A U-100 display scale represents 100 units per mL, while a U-40 display scale represents 40 units per mL. These are scale definitions, not product directions.

A syringe unit is not a mass unit. The calculator must first have a concentration derived from the visitor’s entered mass and liquid volume.

Limitations

  • Arithmetic cannot validate a label, assay, identity, sterility, formulation, or clinical indication. It cannot resolve a mismatch between a product label and the values entered. It cannot convert research findings into a personal decision and cannot determine whether a result is suitable for a person.

Frequently asked questions

What does this SS-31 calculator calculate?

It uses the visitor’s entered mass, liquid volume, amount to calculate, and display scale to return concentration, a calculated mL value, and a calculated syringe-scale position.

Does PepLedger select an elamipretide amount?

No. PepLedger does not determine or recommend an amount. It performs arithmetic using values entered by the visitor.

Does FDA approval of Forzinity apply to every SS-31 container?

No. The FDA approval is product- and indication-specific. A related name on a container does not establish that the container is Forzinity or covered by its labeling.

Why does changing liquid volume change concentration?

For a fixed entered mass, concentration is the mass divided by the entered volume. Changing that volume changes the quotient, so the later mL representation changes as well.

Can syringe units identify an elamipretide mass by themselves?

No. Syringe units describe a volume scale. A concentration and a consistent unit system are required before a mass can be represented.

What is the status of SS-31 research?

Elamipretide has an FDA accelerated-approval product context for Barth syndrome, alongside continuing research. The approval should not be generalized to other uses or unlabelled materials.

Sources and official references

Calculation methodology

PepLedger calculates concentration, liquid volume and syringe-scale position exclusively from the values you enter. It does not choose or recommend an amount.

View our calculation methodology and editorial standards

Last updated: September 13, 2026

Related tools